Complement component C3–The “Swiss Army Knife” of innate immunity and host defense
As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
Complement in disease: a defence system turning offensive
D Ricklin, ES Reis, JD Lambris - Nature Reviews Nephrology, 2016 - nature.com
Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …
versatile, yet potentially more harmful side of this innate immune pathway as an …
The first case of COVID-19 treated with the complement C3 inhibitor AMY-101
S Mastaglio, A Ruggeri, AM Risitano, P Angelillo… - Clinical …, 2020 - Elsevier
Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-
19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence …
19 pneumonia and is mainly based on an immune-driven pathology. Mounting evidence …
The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis
F Lupu, G Kinasewitz, K Dormer - Journal of cellular and …, 2020 - Wiley Online Library
Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …
Thromboinflammation in acute injury: infections, heatstroke, and trauma
Tissue microcirculation is essential for the maintenance of organ homeostasis. Following
acute infections, activation of coagulation and inflammation, which are critical …
acute infections, activation of coagulation and inflammation, which are critical …
[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation
Y Li, H Li, S Liu, P Pan, X Su, H Tan, D Wu, L Zhang… - Molecular …, 2018 - Elsevier
Acute respiratory distress syndrome (ARDS) is a severe clinical disorder characterized by its
acute onset, diffuse alveolar damage, intractable hypoxemia, and non-cardiogenic …
acute onset, diffuse alveolar damage, intractable hypoxemia, and non-cardiogenic …
Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases
T Isshiki, S Naiel, M Vierhout, K Otsubo, P Ali… - Pharmacology & …, 2023 - Elsevier
The treatment of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF),
remains challenging as current available antifibrotic agents are not effective in halting …
remains challenging as current available antifibrotic agents are not effective in halting …
Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis
Complement is one of the most ancient defense systems. It gets strongly activated
immediately after acute injuries like trauma, burn, or sepsis and helps to initiate …
immediately after acute injuries like trauma, burn, or sepsis and helps to initiate …
[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know
WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …