C ryptococcus is a potentially fatal fungal pathogen and a leading cause of death in
immunocompromised patients. As an opportunistic and facultative intracellular pathogen of …

After inhalation of infectious particles, Cryptococcus neoformans resides in the alveolar
spaces, where it can survive and replicate in the extracellular environment. This yeast has …

The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in
immunocompromised patients. Macrophages are central to the host response to cryptococci; …

Abstract The Pacific Northwest outbreak of cryptococcosis, caused by a near-clonal lineage
of the fungal pathogen Cryptococcus gattii, represents the most significant cluster of life …

Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

WASP and SCAR homologue (WASH) is a recently identified and evolutionarily conserved
regulator of actin polymerization. In this paper, we show that WASH coats mature …

Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of
the cells during infection. In particular, this process can occur by enlarging the size of the …

Microglia provide protection against a range of brain infections including bacteria, viruses
and parasites, but how these glial cells respond to fungal brain infections is poorly …

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

Cryptococcus gattii is an emerging intracellular pathogen and the cause of the largest
primary outbreak of a life-threatening fungal disease in a healthy population. Outbreak …