Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …

Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or
epigenetic changes, and is the biggest challenge around the world. Cytokines, including …

The chemokine CXCL12 (SDF-1) and its cell surface receptor CXCR4 were first identified as
regulators of lymphocyte trafficking to the bone marrow. Soon after, the CXCL12/CXCR4 …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Chemokines are crucial autocrine and paracrine players in tumor development. In particular,
CXCL12, through its receptors CXCR4 and CXCR7, affects tumor progression by controlling …

The CXC chemokine receptor type 4 (CXCR4) receptor and its ligand, CXCL12, are
overexpressed in various cancers and mediate tumor progression and hypoxia-mediated …

Migration of cells toward chemical cues, or chemotaxis, is important for many biologic
processes such as immune defense, wound healing and cancer metastasis. Although …

Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells
and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling …

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal
melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic …