Ageing is associated with a progressive degeneration of the tissues, which has a negative
impact on the structure and function of vital organs and is among the most important known …

Low exercise tolerance has a large influence on health status in chronic obstructive
pulmonary disease and chronic heart failure. In addition to primary organ dysfunction …

We identified the main changes in serum metabolites associated with severe (n= 46) and
mild (n= 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …

Protein synthesis, in particular peptide-chain elongation, consumes cellular energy. Anoxia
activates AMP-activated protein kinase (AMPK, see [1]), resulting in the inhibition of …

The ischemic threshold of protein synthesis and energy state was determined 1, 6, and 12 h
after middle cerebral artery (MCA) occlusion in rats. Local blood flow and amino acid …

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. It has been projected to move from the sixth to the third most common cause of …

Anemia in childhood is defined as a hemoglobin (Hb) concentration below cut off levels
established by the World Health Organization:< 11 g/dl in children aged 6–59 months,< 11.5 …

SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress,
hypoxia and impaired physical activity. These factors all together contribute to muscle …

Skeletal muscle is a metabolically active tissue and the major body protein reservoir. Drop in
ambient oxygen pressure likely results in a decrease in muscle cells oxygenation, reactive …

Background The aim of this review is to assess the current understanding of the regulation of
protein synthesis and degradation in striated muscle, a tissue which constitutes the largest …