Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

The epigenome consists of the DNA methylation marks and histone modifications involved
in controlling gene expression. It is accurately reproduced during mitosis and can be …

Epigenetics is the study of the heritable changes in gene expression that occur without a
change in the DNA sequence itself. These heritable epigenetic changes include chromatin …

Recent studies have revealed mechanistic parallels between imprinted X-chromosome
inactivation and autosomal imprinting. We suggest that neither mechanism was present in …

The epigenetic phenomenon of genomic imprinting provides an additional level of gene
regulation that is confined to a limited number of genes, frequently, but not exclusively …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

Among mammals, only eutherians and marsupials are viviparous and have genomic
imprinting that leads to parent-of-origin-specific differential gene expression. We used …

Comparisons between eutherians and marsupials suggest limited conservation of the
molecular mechanisms that control genomic imprinting in mammals. We have studied the …

Imprinted genes, which are expressed from a single parental allele in response to
epigenetic marks first established in the germline, function in a myriad of processes to …

Genomic imprinting is a parent-of-origin-specific expression phenomenon that plays
fundamental roles in many biological processes. In animals, imprinting is only observed in …