Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin
Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …
have enabled the use of engineered biological systems toward a more sustainable energy …
Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products
Highlights•Depolymerized lignin is a complex and variable mix of aromatic compounds.•Non-
model microbes can convert these aromatic compounds to useful products.•Known microbial …
model microbes can convert these aromatic compounds to useful products.•Known microbial …
Catabolic pathway acquisition by rhizosphere bacteria readily enables growth with a root exudate component but does not affect root colonization
S Christel, AA Carrell, LH Hochanadel… - mBio, 2024 - journals.asm.org
Horizontal gene transfer (HGT) is a fundamental evolutionary process that plays a key role in
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …
Synthetic biology towards engineering microbial lignin biotransformation
AL Yaguchi, SJ Lee, MA Blenner - Trends in Biotechnology, 2021 - cell.com
Lignin is the second most abundant biopolymer on earth and is a major source of aromatic
compounds; however, it is vastly underutilized owing to its heterogeneous and recalcitrant …
compounds; however, it is vastly underutilized owing to its heterogeneous and recalcitrant …
Modular engineering of biomass degradation pathways
Production of fuels and chemicals from renewable lignocellulosic feedstocks is a promising
alternative to petroleum-derived compounds. Due to the complexity of lignocellulosic …
alternative to petroleum-derived compounds. Due to the complexity of lignocellulosic …
Pyridoxal and α-ketoglutarate independently improve function of Saccharomyces cerevisiae Thi5 in the metabolic network of Salmonella enterica
MD Paxhia, DM Downs - Journal of Bacteriology, 2022 - Am Soc Microbiol
Microbial metabolism is often considered modular, but metabolic engineering studies have
shown that transferring pathways, or modules, between organisms is not always …
shown that transferring pathways, or modules, between organisms is not always …
Catabolic pathway acquisition by soil pseudomonads readily enables growth with salicyl alcohol but does not affect colonization of Populus roots
Horizontal gene transfer (HGT) is a fundamental evolutionary process that plays a key role in
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …
The Inhibition of Bacterial IMPDHs by Mutagenesis and Kinetic Studies
X Wang - 2022 - search.proquest.com
Abstract Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the oxidation of IMP
to XMP, which is the rate-limiting step of de novo guanine nucleotide biosynthesis. The …
to XMP, which is the rate-limiting step of de novo guanine nucleotide biosynthesis. The …