Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin

AJ Borchert, WR Henson, GT Beckham - Current opinion in biotechnology, 2022 - Elsevier
Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …

Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products

CC Azubuike, MN Allemann, JK Michener - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Depolymerized lignin is a complex and variable mix of aromatic compounds.•Non-
model microbes can convert these aromatic compounds to useful products.•Known microbial …

Catabolic pathway acquisition by rhizosphere bacteria readily enables growth with a root exudate component but does not affect root colonization

S Christel, AA Carrell, LH Hochanadel… - mBio, 2024 - journals.asm.org
Horizontal gene transfer (HGT) is a fundamental evolutionary process that plays a key role in
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …

Synthetic biology towards engineering microbial lignin biotransformation

AL Yaguchi, SJ Lee, MA Blenner - Trends in Biotechnology, 2021 - cell.com
Lignin is the second most abundant biopolymer on earth and is a major source of aromatic
compounds; however, it is vastly underutilized owing to its heterogeneous and recalcitrant …

Modular engineering of biomass degradation pathways

JE Chaves, GN Presley, JK Michener - Processes, 2019 - mdpi.com
Production of fuels and chemicals from renewable lignocellulosic feedstocks is a promising
alternative to petroleum-derived compounds. Due to the complexity of lignocellulosic …

Pyridoxal and α-ketoglutarate independently improve function of Saccharomyces cerevisiae Thi5 in the metabolic network of Salmonella enterica

MD Paxhia, DM Downs - Journal of Bacteriology, 2022 - Am Soc Microbiol
Microbial metabolism is often considered modular, but metabolic engineering studies have
shown that transferring pathways, or modules, between organisms is not always …

Catabolic pathway acquisition by soil pseudomonads readily enables growth with salicyl alcohol but does not affect colonization of Populus roots

S Christel, AA Carrell, LH Burdick, MI Villalobos Solis… - bioRxiv, 2024 - biorxiv.org
Horizontal gene transfer (HGT) is a fundamental evolutionary process that plays a key role in
bacterial evolution. The likelihood of a successful transfer event is expected to depend on …

The Inhibition of Bacterial IMPDHs by Mutagenesis and Kinetic Studies

X Wang - 2022 - search.proquest.com
Abstract Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the oxidation of IMP
to XMP, which is the rate-limiting step of de novo guanine nucleotide biosynthesis. The …