Pharmacokinetics, pharmacodynamics and pharmacogenetics of tacrolimus in kidney transplantation
M Yu, M Liu, W Zhang, Y Ming - Current drug metabolism, 2018 - ingentaconnect.com
Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …
immunosuppressant which consists of the footstone as immunosuppressive regimens in …
Effect of CYP3A5* 3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies
The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of
kidney transplant patients. This variability has been attributed to the genetic polymorphism of …
kidney transplant patients. This variability has been attributed to the genetic polymorphism of …
[HTML][HTML] Gut microbiota and tacrolimus dosing in kidney transplantation
Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a
challenging task because of much interpatient and intrapatient variability in drug absorption …
challenging task because of much interpatient and intrapatient variability in drug absorption …
[HTML][HTML] Application of machine-learning models to predict tacrolimus stable dose in renal transplant recipients
J Tang, R Liu, YL Zhang, MZ Liu, YF Hu, MJ Shao… - Scientific reports, 2017 - nature.com
Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our
goal was to compare the performance of multiple linear regression (MLR) and eight machine …
goal was to compare the performance of multiple linear regression (MLR) and eight machine …
[HTML][HTML] Predicting blood concentration of tacrolimus in patients with autoimmune diseases using machine learning techniques based on real-world evidence
P Zheng, Z Yu, L Li, S Liu, Y Lou, X Hao, P Yu… - Frontiers in …, 2021 - frontiersin.org
Tacrolimus is a widely used immunosuppressive drug in patients with autoimmune
diseases. It has a narrow therapeutic window, thus requiring therapeutic drug monitoring …
diseases. It has a narrow therapeutic window, thus requiring therapeutic drug monitoring …
[HTML][HTML] Impact of the CYP3A5, CYP3A4, COMT, IL-10 and POR Genetic Polymorphisms on Tacrolimus Metabolism in Chinese Renal Transplant Recipients
Tacrolimus is a widely used immunosuppressive drug for preventing the rejection of solid
organ transplants. The efficacy of tacrolimus shows considerable variability, which might be …
organ transplants. The efficacy of tacrolimus shows considerable variability, which might be …
[HTML][HTML] Combination analysis in genetic polymorphisms of drug-metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese …
T Ota, Y Kamada, M Hayashida… - … journal of medical …, 2015 - ncbi.nlm.nih.gov
The Cytochrome P450 is the major enzyme involved in drug metabolism. CYP enzymes are
responsible for the metabolism of most clinically used drugs. Individual variability in CYP …
responsible for the metabolism of most clinically used drugs. Individual variability in CYP …
[HTML][HTML] Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation
K Thishya, KK Vattam, SM Naushad, SB Raju… - PLoS …, 2018 - journals.plos.org
The objective of the current study was to explore the role of ABCB1 and CYP3A5 genetic
polymorphisms in predicting the bioavailability of tacrolimus and the risk for post-transplant …
polymorphisms in predicting the bioavailability of tacrolimus and the risk for post-transplant …
Which genetic determinants should be considered for tacrolimus dose optimization in kidney transplantation? A combined analysis of genes affecting the CYP3A locus
H Bruckmueller, AN Werk, L Renders… - Therapeutic drug …, 2015 - journals.lww.com
Background: Tacrolimus is established as immunosuppressant after kidney transplantation.
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients
Y Li, X Hu, B Cai, J Chen, Y Bai, J Tang, Y Liao… - Transplant …, 2012 - Elsevier
BACKGROUND: The published data revealed conflicting results of the polymorphism of
MDR1 exon 26 SNP C3435T on the pharmacokinetics of tacrolimus in different post …
MDR1 exon 26 SNP C3435T on the pharmacokinetics of tacrolimus in different post …