Pulmonary fibrosis and architectural remodeling of tissues can severely disrupt lung
function, often with fatal consequences. The etiology of pulmonary fibrotic diseases is varied …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

Background Mast cell localization within the airway smooth muscle (ASM)‐bundle plays an
important role in the development of airway hyper‐responsiveness (AHR). Genomewide …

Mast cells (MC s) play a central role in tissue homoeostasis, sensing the local environment
through numerous innate cell surface receptors. This enables them to respond rapidly to …

Fibrosis is a medical condition characterized by an excessive deposition of extracellular
matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases …

BACKGROUND: Increased numbers of mast cells are present in the esophageal epithelium
in patients with eosinophilic esophagitis (EE). However, mast cell infiltration into the …

Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as
numerous hematopoietic cells, which are central to the pathogenesis of asthma. Objectives …

The pathogenesis of asthma includes a complex interplay among airway inflammation,
hyperresponsiveness, and remodeling. Current evidence suggests that airway structural …

Severe asthma patients with low type 2 inflammation derive less clinical benefit from
therapies targeting type 2 cytokines and represent an unmet need. We show that mast cell …

Angiogenesis is a complex process finely regulated by the balance between angiogenesis
stimulators and inhibitors. As a result of proangiogenic factors overexpression, it plays a …