The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

The major drainage structures for aqueous humor (AH) are the conventional or trabecular
outflow pathways, which are comprised of the trabecular meshwork (made up by the uveal …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

Glaucoma is a progressive and chronic neurodegenerative disorder characterized by
damage to the inner layers of the retina and deformation of the optic nerve head. The …

Changes in aqueous humor dynamics with age and in glaucoma have been studied for
several decades. More recently, techniques have been developed which confirm earlier …

Aqueous humor outflow resistance is the primary determinant of intraocular pressure (IOP),
and increased outflow resistance is the basis for elevated IOP associated with glaucoma …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

Background Glaucoma is a group of optic neuropathies in which damage to the optic nerve
results in a distinctive pattern of irreversible vision loss. Elevations in the intraocular …

The trabecular meshwork forms most of the resistance to aqueous humor outflow needed for
maintenance of a pressure gradient between intraocular pressure of∼ 17 mmHg and …