Viral DNA genomes have limited coding capacity and therefore harness cellular factors to
facilitate replication of their genomes and generate progeny virions. Studies of viruses and …

The ataxia–telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated
in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize …

DNA double-strand breaks (DSBs) are among the most cytotoxic types of DNA damage,
which if left unrepaired can lead to mutations or gross chromosomal aberrations, and …

Viruses employ a variety of strategies to usurp and control cellular activities through the
orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear …

It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …

Microtubules (MTs) form a rapidly adaptable network of filaments that radiate throughout the
cell. These dynamic arrays facilitate a wide range of cellular processes, including the …

During infection, viruses attempt to hijack the cell while the host responds with various
defense systems. Traditional defenses include the interferon response and apoptosis, but …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

Cells infected by adenovirus E4 mutants accumulate end-to-end concatemers of the viral
genome that are assembled from unit-length viral DNAs by nonhomologous end joining …

Viruses must interact with their hosts in order to replicate; these interactions often provoke
the evolutionarily conserved response to DNA damage, known as the DNA damage …