[HTML][HTML] Wound healing: a cellular perspective

M Rodrigues, N Kosaric, CA Bonham… - Physiological …, 2018 - journals.physiology.org
Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Acute inflammation in tissue healing

AM Soliman, DR Barreda - International Journal of Molecular Sciences, 2022 - mdpi.com
There are well-established links between acute inflammation and successful tissue repair
across evolution. Innate immune reactions contribute significantly to pathogen clearance …

[HTML][HTML] SFRP2/DPP4 and FMO1/LSP1 define major fibroblast populations in human skin

T Tabib, C Morse, T Wang, W Chen… - Journal of Investigative …, 2018 - Elsevier
Fibroblasts produce matrix, regulate inflammation, mediate reparative processes, and serve
as pluripotent mesenchymal cells. Analyzing digested normal human skin by single-cell …

Reengineering the tumor microenvironment to alleviate hypoxia and overcome cancer heterogeneity

JD Martin, D Fukumura… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Solid tumors consist of cancer cells and stromal cells, including resident and transiting
immune cells—all ensconced in an extracellular matrix (ECM)—nourished by blood vessels …

Abnormal RNA stability in amyotrophic lateral sclerosis

EM Tank, C Figueroa-Romero, LM Hinder… - Nature …, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features,
including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA …

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

L Menendez, T Trecek, S Gopalakrishnan, L Tao… - elife, 2020 - elifesciences.org
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

JM Replogle, W Zhou, AE Amaro… - Proceedings of the …, 2020 - National Acad Sciences
Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient
prognosis in many cancer types. However, the condition causes cellular stress and cell cycle …

Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction

T Kageyama, A Shimizu, R Anakama, R Nakajima… - Science …, 2022 - science.org
During embryonic development, reciprocal interactions between epidermal and
mesenchymal layers trigger hair follicle morphogenesis. This study revealed that …

Cell competition during reprogramming gives rise to dominant clones

N Shakiba, A Fahmy, G Jayakumaran, S McGibbon… - Science, 2019 - science.org
INTRODUCTION Recent advances in lineage tracking using DNA-based barcoding
technologies have provided new insights into the developmental dynamics of cell …

Cytotoxicity and transcriptomic analysis of silver nanoparticles in mouse embryonic fibroblast cells

S Gurunathan, M Qasim, C Park, H Yoo… - International journal of …, 2018 - mdpi.com
The rapid development of nanotechnology has led to the use of silver nanoparticles (AgNPs)
in biomedical applications, including antibacterial, antiviral, anti-inflammatory, and …