West Nile virus: an update on pathobiology, epidemiology, diagnostics, control and “one health” implications
West Nile virus (WNV) is an important zoonotic flavivirus responsible for mild fever to severe,
lethal neuroinvasive disease in humans, horses, birds, and other wildlife species. Since its …
lethal neuroinvasive disease in humans, horses, birds, and other wildlife species. Since its …
The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker
The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and
mechanistic function have remained somewhat elusive ever since it was first reported in …
mechanistic function have remained somewhat elusive ever since it was first reported in …
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination
PR Beatty, H Puerta-Guardo, SS Killingbeck… - Science translational …, 2015 - science.org
The four dengue virus serotypes (DENV1 to DENV4) are mosquito-borne flaviviruses that
cause up to~ 100 million cases of dengue annually worldwide. Severe disease is thought to …
cause up to~ 100 million cases of dengue annually worldwide. Severe disease is thought to …
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity
Complications arising from dengue virus infection include potentially fatal vascular leak, and
severe disease has been linked with excessive immune cell activation. An understanding of …
severe disease has been linked with excessive immune cell activation. An understanding of …
Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction
Medically important flaviviruses cause diverse disease pathologies and collectively are
responsible for a major global disease burden. A contributing factor to pathogenesis is …
responsible for a major global disease burden. A contributing factor to pathogenesis is …
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system
Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne
encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. The …
encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. The …
Dengue virus
A Murugesan, M Manoharan - Emerging and reemerging viral pathogens, 2020 - Elsevier
Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …
Dengue virus non-structural protein 1 modulates infectious particle production via interaction with the structural proteins
Non-structural protein 1 (NS1) is one of the most enigmatic proteins of the Dengue virus
(DENV), playing distinct functions in immune evasion, pathogenesis and viral replication …
(DENV), playing distinct functions in immune evasion, pathogenesis and viral replication …
Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components
Dengue virus (DENV) is the most prevalent, medically important mosquito-borne virus.
Disease ranges from uncomplicated dengue to life-threatening disease, characterized by …
Disease ranges from uncomplicated dengue to life-threatening disease, characterized by …
The role of host cholesterol during flavivirus infection
JF Osuna-Ramos, JM Reyes-Ruiz… - Frontiers in cellular and …, 2018 - frontiersin.org
In recent years the emergence and resurgence of arboviruses have generated a global
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …
health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and …