Parkinson's disease (PD) is the second most common neurodegenerative disorder and the
fastest growing neurologic disease in the world, yet no disease-modifying therapy is …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

In Parkinson's disease oxidative stress and calcium-induced excitotoxicity have been
considered important mechanisms leading to cell death for decades, but the factors that …

In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …

Parkinson disease (PD) is the second most common neurodegenerative disease after
Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which progressive loss of self-
tolerance, evidenced by accumulation of auto-antibodies and auto-reactive T cells that …

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by hyperglycemia
due to progressive immune-mediated destruction of insulin-producing pancreatic islet β …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic β cell
destruction induced by islet reactive T cells that have escaped central tolerance. Many …

Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by neuroinflammation, formation of Lewy bodies, and progressive loss of …