Inflammation has been reported to be intimately linked to the development or worsening of
several non-infectious diseases. A number of chronic conditions such as cancer, diabetes …

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Inflammation is associated with many neurodegenerative diseases, including Alzheimer's
disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Studies have shown that transforming growth factor-β (TGF-β) and interleukin 6 (IL-6) are
required for the lineage commitment of pathogenic IL-17-producing T helper cells (TH-17 …

Microglia are key players of the immune response in the central nervous system (CNS) and,
being the resident innate immune cells, they are responsible for the early control of …

The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being
appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL …