Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …

Accumulation of deoxyribonucleic acid (DNA) damage diminishes cellular health, increases
risk of developmental and degenerative diseases, and accelerates aging. Optimizing …

The question of what constitutes an acceptable risk is a matter of judgement. Such decisions
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …

The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively
used as a biomarker of chromosomal damage and genome stability in human populations …

The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive
method for monitoring genetic damage in humans. This overview has concluded that …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

By the early 1980s, epidemiologists had identified many important causes of cancer. They
had also proposed the'multi-stage'model of cancer, although none of the hypothesized …

A deficiency of any of the micronutrients: folic acid, Vitamin B12, Vitamin B6, niacin, Vitamin
C, Vitamin E, iron, or zinc, mimics radiation in damaging DNA by causing single-and double …

Cancer genetics has for many years focused on mutational events that have their primary
effect within the cancer cell. Recently that focus has widened, with evidence of the …

This report reviews the literature on the genotoxicity of mainstream tobacco smoke and
cigarette smoke condensate (CSC) published since 1985. CSC is genotoxic in nearly all …