Abstract mRNA translation is a crucial process that leads to protein synthesis in living cells.
Therefore, it is a process that needs to work optimally for a cell to stay healthy and alive. With …

The in vitro transcription (IVT) reaction used in the production of messenger RNA vaccines
and therapies remains poorly quantitatively understood. Mechanistic modeling of IVT could …

The well established phenomenon of ribosome drop-off plays crucial roles in translational
accuracy and nutrient starvation responses during protein translation. When cells are under …

The mechanisms leading to the accumulation of the SMC complexes condensins around
specific transcription units remain unclear. Observations made in bacteria suggested that …

Molecular motors of the kinesin-1 family move in a directed and processive fashion along
microtubules. It is generally accepted that steric hindrance of motors leads to crowding …

In fast-transcribing prokaryotic genes, such as an rrn gene in Escherichia coli, many RNA
polymerases (RNAPs) transcribe the DNA simultaneously. Active elongation of RNAPs is …

We extend the paradigmatic and versatile totally asymmetric simple exclusion process
(TASEP) for stochastic 1D transport to allow for two different particle species, each having …

The process of transcription initiation and elongation are primary points of control in the
regulation of gene expression. Although biochemical studies have uncovered the …

Several important biological processes are initiated by the binding of a protein to a specific
site on the DNA. The strategy adopted by a protein, called transcription factor (TF), for …

We investigate the totally asymmetric simple exclusion process (TASEP) in the presence of
obstacles that dynamically bind and unbind from the lattice. The model is motivated by …