Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei

NP Crilly, MR Mugnier - PLoS pathogens, 2021 - journals.plos.org
Trypanosoma brucei is a protozoan parasite that causes human and animal African
trypanosomiases (HAT and AAT). In the mammalian host, the parasite lives entirely …

Adipocyte lipolysis protects mice against Trypanosoma brucei infection

H Machado, P Hofer, R Zechner, TK Smith… - Nature …, 2023 - nature.com
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and
inducing weight loss. Here we investigated the molecular mechanisms responsible for …

γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

JF Quintana, MC Sinton, P Chandrasegaran… - Nature …, 2023 - nature.com
African trypanosomes colonise the skin to ensure parasite transmission. However, how the
skin responds to trypanosome infection remains unresolved. Here, we investigate the local …

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

A review on the diagnosis of animal trypanosomoses

M Desquesnes, M Gonzatti, A Sazmand, S Thévenon… - Parasites & …, 2022 - Springer
This review focuses on the most reliable and up-to-date methods for diagnosing
trypanosomoses, a group of diseases of wild and domestic mammals, caused by …

Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance …

MK N'djetchi, O Camara, M Koffi, M Camara… - Infectious Diseases of …, 2024 - mednexus.org
Background Serological screening tests play a crucial role to diagnose gambiense human
African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic …

Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei

AK Beaver, Z Keneskhanova, RO Cosentino, BL Weiss… - Nature, 2024 - nature.com
The protozoan parasite Trypanosoma brucei evades clearance by the host immune system
through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically …

Induced transient immune tolerance in ticks and vertebrate host: a keystone of tick-borne diseases?

N Boulanger, S Wikel - Frontiers in immunology, 2021 - frontiersin.org
Ticks and tick transmitted infectious agents are increasing global public health threats due to
increasing abundance, expanding geographic ranges of vectors and pathogens, and …

Prevalence of blood and skin trypanosomes in domestic and wild fauna from two sleeping sickness foci in Southern Cameroon

EMK Magang, RMN Kamga, J Telleria… - PLoS Neglected …, 2023 - journals.plos.org
Although studies on African Trypanosomiases revealed a variety of trypanosome species in
the blood of various animal taxa, animal reservoirs of Trypanosoma brucei gambiense and …