The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The centromere is responsible for accurate chromosome segregation. Mammalian
centromeres are specified epigenetically, with all active centromeres containing centromere …

The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric
chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA …

The assembly of just a single kinetochore at the centromere of each sister chromatid is
essential for accurate chromosome segregation during cell division. Surprisingly, despite …

Assembly, mobilization and disassembly of nucleosomes can influence the regulation of
gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome …

Centromeres are chromosomal elements that are both necessary and sufficient for
chromosome segregation. However, the puzzlingly broad range in centromere complexity …

The centromere/kinetochore complex is indispensable for accurate segregation of
chromosomes during cell divisions when it serves as the attachment site for spindle …

In mammalian females, two X chromosomes are epigenetically distinguished as active and
inactive chromosomes to balance X-linked gene dosages between males and females. How …