[HTML][HTML] Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia

N Lin, W Fu, C Zhao, B Li, X Yan, Y Li - Biochemical and biophysical …, 2017 - Elsevier
Abstract DNA methyltransferase 3A (DNMT3A) catalyzes de novo DNA methylation and
plays important roles in the pathogenesis of acute myeloid leukemia. However, the …

Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia

T Tabatabaei, MR Rezvany, B Ghasemi… - BioMed Research …, 2024 - Wiley Online Library
Epigenetic alterations have been observed in many hematological malignancies, including
acute myeloid leukemia (AML). Many of these alterations result from mutations in DNA …

[HTML][HTML] CD7-positive leukemic blasts with DNMT3A mutations predict poor prognosis in patients with acute myeloid leukemia

Y Bai, X Sun, M Li, X Niu, W Cao, J Niu, X Xiao… - Frontiers in …, 2024 - frontiersin.org
Background DNMT3A mutations can be detected in premalignant hematopoietic stem cells
and are primarily associated with clonal hematopoiesis of indeterminate potential; however …

Expression analysis of BECN1 in acute myeloid leukemia: association with distinct cytogenetic and molecular abnormalities

D Zare‐Abdollahi, S Safari, A Movafagh… - International Journal …, 2016 - Wiley Online Library
Introduction In acute myeloid leukemia (AML), it has been shown that AML‐derived cells
often remain sensitive to autophagy‐inducing stimuli, leading to the idea that harnessing the …

[HTML][HTML] DNA 甲基转移酶3A 基因突变急性髓系白血病患者临床特征及预后研究

齐悦, 高素君, 林海, 谭业辉, 刘秋菊… - Chinese Journal of …, 2019 - ncbi.nlm.nih.gov
DNA甲基转移酶3A基因突变急性髓系白血病患者临床特征及预后研究- PMC Back to Top Skip to
main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content …

DNMT3A mutations in Chinese childhood acute myeloid leukemia

W Li, L Cui, C Gao, S Liu, X Zhao, R Zhang, H Zheng… - Medicine, 2017 - journals.lww.com
Background: DNA methyltransferase 3A (DNMT3A) mutations have been found in
approximately 20% of adult acute myeloid leukemia (AML) patients and in 0% to 1.4% of …

Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib

J Gu, Z Wang, M Xiao, X Mao, L Zhu… - Cancer Biology & …, 2017 - Taylor & Francis
Chronic myelomonocytic leukemia (CMML) is a heterogeneous neoplastic hematologic
disorder with worse overall survival. Half of CMML have mutations, but case with …

急性髓细胞白血病中DNMT3A 亚型1、 2 的表达及其临床意义

林娜, 王蕾, 李艳, 颜晓菁 - 临床血液学杂志, 2018 - whuhzzs.com
目的: 检测急性髓细胞白血病(AML) 患者骨髓标本中DNA 甲基转移酶3A (DNMT3A) 亚型1, 2
的表达情况, 分析其临床意义. 方法: 应用SYBR Green real-time PCR 方法检测DNMT3A1 …

The clinical characteristics and prognoses of de novo acute myeloid leukemia patients with DNA methyltransferase 3A gene mutations

Y Qi, SJ Gao, H Lin, YH Tan, QJ Liu, JN Sun… - Zhonghua xue ye xue …, 2019 - europepmc.org
齐悦 高素君 林海 谭业辉 刘秋菊 孙京男 梁新悦 苏龙 胡瑞萍 李薇吉林大学第一医院肿瘤中心
血液科, 长春 130021 通信作者: 高素君, Email: sujung1963@ sina. com 基金项目 …

[HTML][HTML] ND4 mutations are more prevalent in patients with acute myeloid leukemia of M2 morphology

M Xu, XL Zhao, Y Zhu, WY Shen, M Hong… - Translational Cancer …, 2018 - tcr.amegroups.org
Background: To evaluate the prognostic value of ND4 gene mutation and other gene
mutations in acute myeloid leukemia (AML) patients, especially among those without …