Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Background Persons with toxic gain-of-function variants in the gene encoding
apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive …

Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Background Among patients in the United States with chronic kidney disease, black patients
are at increased risk for end-stage renal disease, as compared with white patients. Methods …

Abstract The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter,
longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 …

Objective Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus
(SLE) that exhibits familial aggregation and may progress to endstage renal disease …