Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency
and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant …

Background Imipenem combined with the β-lactamase inhibitor relebactam has broad
antibacterial activity, including against carbapenem-resistant gram-negative pathogens. We …

The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been
hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific …

Multidrug resistance (MDR) represents a serious global threat due to the rapid global spread
and limited antimicrobial options for treatment of difficult-to-treat (DTR) infections sustained …

Antibiotics, a power tool to combat pathogenic bacterial infection, have experienced their
inability to kill drug-resistant bacteria due to the development of antibiotic resistance. As an …

Active bacterial metabolism is a prerequisite for optimal activity of many classes of
antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic …

High-resistance rates in carbapenem-resistant GNB in many countries will inevitably
complicate treatment of serious infections in vulnerable patient groups and should …

This analysis of the global clinical antibacterial pipeline was done in support of the Global
Action Plan on Antimicrobial Resistance. The study analysed to what extent antibacterial …