CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
T cell exhaustion
EJ Wherry - Nature immunology, 2011 - nature.com
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
[HTML][HTML] T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Summary The SARS-CoV-2 Omicron variant (B. 1.1. 529) contains mutations that mediate
escape from antibody responses, although the extent to which these substitutions in spike …
escape from antibody responses, although the extent to which these substitutions in spike …
[HTML][HTML] Distinct viral reservoirs in individuals with spontaneous control of HIV-1
Sustained, drug-free control of HIV-1 replication is naturally achieved in less than 0.5% of
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
infected individuals (here termed 'elite controllers'), despite the presence of a replication …
[HTML][HTML] Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
Abstract Characterization of human monoclonal antibodies is providing considerable insight
into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane …
into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane …
Tuberculosis and HIV co-infection
A Pawlowski, M Jansson, M Sköld… - PLoS …, 2012 - journals.plos.org
Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems
and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most …
and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most …
HIV infection
More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …
virus (HIV), and there are now approximately 37 million individuals living with the infection …
[HTML][HTML] MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
A Kurioka, JE Ussher, C Cosgrove, C Clough… - Mucosal …, 2015 - Elsevier
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …
TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells
T Sekine, A Perez-Potti, S Nguyen, JB Gorin… - Science …, 2020 - science.org
CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …