The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Abstract Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important
transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master …

Increasing evidence suggests that chromatin modifications have important roles in
modulating constitutive or alternative splicing. Here we demonstrate that the PWWP domain …

Menin displays the unique ability to either promote oncogenic function in the hematopoietic
lineage or suppress tumorigenesis in the endocrine lineage; however, its molecular …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

Lens epithelium–derived growth factor p75 splice variant (LEDGF) is a chromatin-binding
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …

Background To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA
genomes into host cell chromosomes. Lentiviral integration is favored in active transcription …

Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …

Considerable success has been achieved in the treatment of HIV-1 infection, and more than
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …