Dual effect of immune cells within tumour microenvironment: pro-and anti-tumour effects and their triggers

AC Peña-Romero, E Orenes-Piñero - Cancers, 2022 - mdpi.com
Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Role of cell surface proteoglycans in cancer immunotherapy

NA Espinoza-Sánchez, M Götte - Seminars in cancer biology, 2020 - Elsevier
Over the past few decades, understanding how tumor cells evade the immune system and
their communication with their tumor microenvironment, has been the subject of intense …

Significance of tumor mutation burden in immune infiltration and prognosis in cutaneous melanoma

K Kang, F Xie, J Mao, Y Bai, X Wang - Frontiers in oncology, 2020 - frontiersin.org
Background: Melanoma is highly immunogenic and therefore suitable for immunotherapy,
but the efficacy is limited by response rate. In several types of tumor, tumor mutation burden …

Nomogram for predicting prognosis of patients with metastatic melanoma after immunotherapy: A Chinese population–based analysis

J Zhao, D Li, S Xie, X Deng, X Wen, J Li, Z Wu… - Frontiers in …, 2022 - frontiersin.org
Background Previous studies indicated the evidence that baseline levels of thyroid
antibodies, thyroid status, and serum lactate dehydrogenase (LDH) and M stage may …

Mining the immunopeptidome for antigenic peptides in cancer

RA León-Letelier, H Katayama, S Hanash - Cancers, 2022 - mdpi.com
Simple Summary The immunopeptidome of cancer cells is a treasure trove of neoantigens
bound to MHC molecules, thus a great source for mining immunopeptides for …

Immunotherapy options for acral melanoma, a fast-growing but neglected malignancy

JA Gajón, A Juarez-Flores, SGDL Rodríguez… - Archives of Medical …, 2022 - Elsevier
Melanoma is the deadliest form of skin cancer. It is classified as cutaneous and non-
cutaneous, with the former characterized by developing in sun-exposed areas of the skin …

Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy

W Zhang, Z He, F Liang, J Gong, L Tan, J Yang… - Journal of Cancer …, 2023 - Springer
Background Previously, albendazole (ABZ) has been reported as an anti-parasitic drug
rather than anti-tumor drug. Our study aim to investigate whether ABZ also has a potential …

The complex role of autophagy in melanoma evolution: new perspectives from mouse models

L Di Leo, V Bodemeyer, D De Zio - Frontiers in Oncology, 2020 - frontiersin.org
Despite tremendous efforts in the last decade to improve treatments, melanoma still
represents a major therapeutic challenge and overall survival of patients remains poor …

Distinct genomic features across cytolytic subgroups in skin melanoma

C Roufas, I Georgakopoulos-Soares… - Cancer Immunology …, 2021 - Springer
Background Skin melanoma is a highly immunogenic cancer. The intratumoral immune
cytolytic activity (CYT) reflects the ability of cytotoxic T and NK cells to eliminate cancer cells …

B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma

A Mohammadi, S Najafi, M Amini… - Melanoma …, 2023 - journals.lww.com
Cutaneous melanoma (CM) is a highly metastatic cancer whose incidence rate is
heightening worldwide. B7H6, as one of the co-stimulatory ligands of the B7 family, is …