The structure of glycosaminoglycans and their interactions with proteins
NS Gandhi, RL Mancera - Chemical biology & drug design, 2008 - Wiley Online Library
Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …
biological processes through the regulation of their various protein partners. Biochemical …
The histophysiology and pathophysiology of the peritoneum
J Van Baal, KK Van de Vijver, R Nieuwland… - Tissue and Cell, 2017 - Elsevier
The peritoneum is an extensive serous organ with both epithelial and mesenchymal features
and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal …
and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal …
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
M Camps, T Rückle, H Ji, V Ardissone, F Rintelen… - Nature medicine, 2005 - nature.com
Abstract Phosphoinositide 3-kinases (PI3K) have long been considered promising drug
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …
CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein-and p42/44 mitogen-activated protein kinase (MAPK) …
WB Fang, I Jokar, A Zou, D Lambert… - Journal of Biological …, 2012 - ASBMB
Increased cell motility and survival are important hallmarks of metastatic tumor cells.
However, the mechanisms that regulate the interplay between these cellular processes …
However, the mechanisms that regulate the interplay between these cellular processes …
IL-33 induces IL-13–dependent cutaneous fibrosis
AL Rankin, JB Mumm, E Murphy, S Turner… - The Journal of …, 2010 - journals.aai.org
IL-33 is constitutively expressed in epithelial barrier tissues, such as skin. Although
increased expression of IL-33/IL-33R has been correlated with fibrotic disorders, such as …
increased expression of IL-33/IL-33R has been correlated with fibrotic disorders, such as …
Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways
MJ Tunon, MV Garcia-Mediavilla… - Current drug …, 2009 - ingentaconnect.com
Flavonoids are a large class of naturally occurring compounds widely present in fruits,
vegetables, and beverages derived from plants. Reports have suggested that these …
vegetables, and beverages derived from plants. Reports have suggested that these …
CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma
P Saintigny, E Massarelli, S Lin, YH Ahn, Y Chen… - Cancer research, 2013 - AACR
CXCR2 in non–small cell lung cancer (NSCLC) has been studied mainly in stromal cells
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …
PI3Kγ inhibition: towards an'aspirin of the 21st century'?
T Rückle, MK Schwarz, C Rommel - Nature reviews Drug discovery, 2006 - nature.com
Class IB phosphatidylinositol 3-kinase p110γ (PI3Kγ) has gained increasing attention as a
promising drug target for the treatment of inflammatory disease. Extensive target-validation …
promising drug target for the treatment of inflammatory disease. Extensive target-validation …
Harnessing bioinformatics to discover new vaccines
MN Davies, DR Flower - Drug discovery today, 2007 - Elsevier
Vaccine design is highly suited to the application of in silico techniques, for both the
discovery and development of new and existing vaccines. Here, we discuss computational …
discovery and development of new and existing vaccines. Here, we discuss computational …
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ
V Pomel, J Klicic, D Covini, DD Church… - Journal of medicinal …, 2006 - ACS Publications
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kγ, have become attractive drug
targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan …
targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan …