Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

The peritoneum is an extensive serous organ with both epithelial and mesenchymal features
and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal …

Abstract Phosphoinositide 3-kinases (PI3K) have long been considered promising drug
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …

Increased cell motility and survival are important hallmarks of metastatic tumor cells.
However, the mechanisms that regulate the interplay between these cellular processes …

IL-33 is constitutively expressed in epithelial barrier tissues, such as skin. Although
increased expression of IL-33/IL-33R has been correlated with fibrotic disorders, such as …

Flavonoids are a large class of naturally occurring compounds widely present in fruits,
vegetables, and beverages derived from plants. Reports have suggested that these …

CXCR2 in non–small cell lung cancer (NSCLC) has been studied mainly in stromal cells
and is known to increase tumor inflammation and angiogenesis. Here, we examined the …

Class IB phosphatidylinositol 3-kinase p110γ (PI3Kγ) has gained increasing attention as a
promising drug target for the treatment of inflammatory disease. Extensive target-validation …

Vaccine design is highly suited to the application of in silico techniques, for both the
discovery and development of new and existing vaccines. Here, we discuss computational …

Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kγ, have become attractive drug
targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan …