The experimental material accumulated in the literature on the conformational behavior of
intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

Abstract “Natively unfolded” proteins occupy a unique niche within the protein kingdom in
that they lack ordered structure under conditions of neutral pH in vitro. Analysis of amino …

The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …

The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is
perplexing in its multitude of molecular functions. In this review we analyse the structure …

The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …

Lipidation is a ubiquitous modification of peptides and proteins that can occur either co‐or
post‐translationally. An array of different lipid classes can adorn proteins and has been …

HIV-1 Nef is expressed in astrocytes, but a contribution to neuropathogenesis and the
development of HIV-associated dementia (HAD) remains uncertain. To determine the …

The Nef protein of the human immunodeficiency virus is as important for disease
progression as it is perplexing in its plethora of target molecules and functions. In this article …

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …