A sesquiterpene lactone, thapsigargin, is a phytochemical found in the roots and fruits of
Mediterranean plants from Thapsia L. species that have been used for centuries in folk …

Cancer is a disorder that rigorously affects the human population worldwide. There is a
steady demand for new remedies to both treat and prevent this life-threatening sickness due …

Tetrahydropyrimidinone derivative was synthesized through one‐pot three components
condensation of 1, 3‐diphenylpyrazole‐4‐carbaldehyde with pentan‐2, 4‐dione and urea …

A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

Naturally occurring terpenoid lactones and their synthetic derivatives have attracted
increasing interest for their promising antitumor activity and potential utilization in the …

Covering: up to the end of 2019 Diverse natural product small molecules have allowed
critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically …

Natural products and leads inspired by them have acted as a probe for successful drug
discovery for many decades. Pain is an obnoxious sensory and emotional experience …

Two series of piperazine-based bis (thieno [2, 3-b] pyridines) and bis (pyrazolo [3, 4-b]
pyridines) were prepared, in good yields, utilizing the appropriate bis (pyridinethione). The …

The α-exo-methylene-γ-butyrolactone moiety is present in a vast array of structurally diverse
natural products and is often central to their biological activity. In this short review, we …

A simple, efficient, cost-effective and environmentally friendly synthesis of new isoxazolyl
pyrido [2, 3-d] pyrimidine derivatives 11 has been developed from 4-amino-3-methyl-5 …