Mechanisms of mechanotransduction and physiological roles of PIEZO channels

B Xiao - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

[HTML][HTML] Vagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope

JW Lovelace, J Ma, S Yadav, K Chhabria, H Shen… - Nature, 2023 - nature.com
Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to
many neurological disorders. The Bezold–Jarisch reflex (BJR), first described, in 1867, is a …

[HTML][HTML] Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

A Handler, Q Zhang, S Pang, TM Nguyen, M Iskols… - Neuron, 2023 - cell.com
Across mammalian skin, structurally complex and diverse mechanosensory end organs
respond to mechanical stimuli and enable our perception of dynamic, light touch. How forces …

Tactile mechanisms and afferents underlying the rat pup transport response

Z Ni, C Neifert, A Rosete, AM Albeely, Y Yang… - Current Biology, 2024 - cell.com
Juvenile rodents and other altricial mammals react with calming, immobility, and postural
modifications to parental pickup, a set of behaviors referred to as the transport response. 1 …

[HTML][HTML] Immunohistochemical detection of PIEZO1 and PIEZO2 in human digital Meissner´ s corpuscles

Y García-Mesa, P Cuendias, M Alonso-Guervós… - Annals of Anatomy …, 2024 - Elsevier
Background The cutaneous end organ complexes or cutaneous sensory corpuscles are
specialized sensory organs associated to low-threshold mechanoreceptors. Mechano-gated …

Mechanosensitive Piezo channels and their potential roles in peripheral auditory perception

Z Yi, G Yin, C Wei, Y Quan, Y Sun - Brain‐X, 2024 - Wiley Online Library
Hearing sound and responding to external and internal mechanical stimuli requires specific
proteins as mechanotransducers that convert mechanical forces into biological signals …

Neurophysiology, Neuro-Immune Interactions, and Mechanobiology in Osteopathy in the Cranial Field: An Evidence-Informed Perspective for a Scientific Rationale

N Barsotti, A Casini, M Chiera, C Lunghi, M Fornari - Healthcare, 2023 - mdpi.com
(1) Background: Osteopathy in the cranial field (OCF) is a distinctive approach within
osteopathy, focusing on the cranial region's manual manipulation. Nevertheless, OCF …

[HTML][HTML] Multi-needle blow-spinning technique for fabricating collagen nanofibrous nerve guidance conduit with scalable productivity and high performance

CY Yang, Z Hou, P Hu, C Li, Z Li, Z Cheng, S Yang… - Materials Today Bio, 2024 - Elsevier
Nerve guidance conduits (NGCs) have been widely accepted as a promising strategy for
peripheral nerve regeneration. Fabricating ideal NGCs with good biocompatibility …

The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria

OO Ojewunmi, TA Adeyemo, AI Oyetunji… - Human Molecular …, 2024 - academic.oup.com
The clinical severity of sickle cell disease (SCD) is strongly influenced by the level of fetal
haemoglobin (HbF) persistent in each patient. Three major HbF loci (BCL11A, HBS1L-MYB …

A functional unbalance of TRPM8 and Kv1 channels underlies orofacial cold allodynia induced by peripheral nerve damage

R Piña, G Ugarte, C Guevara, R Pino… - Frontiers in …, 2024 - frontiersin.org
Cold allodynia is a debilitating symptom of orofacial neuropathic pain resulting from
trigeminal nerve damage. The molecular and neural bases of this sensory alteration are still …