Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

TK Kim, EN Vandsemb, RS Herbst… - Nature Reviews Drug …, 2022 - nature.com
Tumours employ various tactics to adapt and eventually resist immune attack. These
mechanisms are collectively called adaptive immune resistance (AIR). The first defined and …

Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

[HTML][HTML] Clinical cancer immunotherapy: Current progress and prospects

C Liu, M Yang, D Zhang, M Chen, D Zhu - Frontiers in immunology, 2022 - frontiersin.org
Immune checkpoint therapy via PD-1 antibodies has shown exciting clinical value and
robust therapeutic potential in clinical practice. It can significantly improve progression-free …

[HTML][HTML] MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy

AM Cornel, IL Mimpen, S Nierkens - Cancers, 2020 - mdpi.com
In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Targeting innate immune pathways for cancer immunotherapy

LL Cao, JC Kagan - Immunity, 2023 - cell.com
The innate immune system is critical for inducing durable and protective T cell responses to
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …

[HTML][HTML] Challenges and opportunities for pancreatic cancer immunotherapy

AS Bear, RH Vonderheide, MH O'Hara - Cancer cell, 2020 - cell.com
Pancreatic ductal adenocarcinoma (PDA) is among the most immune-resistant tumor types.
Its unique genomic landscape shaped by oncogenic drivers promotes immune suppression …

[HTML][HTML] cGAS-STING, an important pathway in cancer immunotherapy

M Jiang, P Chen, L Wang, W Li, B Chen, Y Liu… - Journal of hematology & …, 2020 - Springer
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …

[HTML][HTML] Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer

S Hegde, VE Krisnawan, BH Herzog, C Zuo… - Cancer cell, 2020 - cell.com
Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …

Epigenetic therapy in immune-oncology

PA Jones, H Ohtani, A Chakravarthy… - Nature Reviews …, 2019 - nature.com
DNA methylation inhibitors have become the mainstay for treatment of certain
haematological malignancies. In addition to their abilities to reactivate genes, including …

[HTML][HTML] Challenges and opportunities in the clinical development of STING agonists for cancer immunotherapy

L Motedayen Aval, JE Pease, R Sharma… - Journal of clinical …, 2020 - mdpi.com
Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have
been effective in only a small subset of patients and a principal mechanism underlying …