Objectives: Concise “synthetic” review of the state of the art of management of acute
ischemic stroke. Data Sources: Available literature on PubMed. Study Selection: We …

Sodium nitroprusside has been used in clinical practice as an arterial and venous
vasodilator for 40 years. This prodrug reacts with physiologic sulfhydryl groups to release …

Key Clinical Points Acute Severe Hypertension Acute severe hypertension that is
accompanied by acute target-organ injury (hypertensive emergency) is associated with …

Importance Asymptomatic blood pressure (BP) elevations are common in hospitalized older
adults, and widespread heterogeneity in the clinical management of elevated inpatient BPs …

Hypertension affects more than one in four adults. The brain is an early target of
hypertension-induced organ damage, and may manifest as stroke, subclinical …

Intracerebral hemorrhages (ICH) represent about 10–15% of all strokes per year in the
United States alone. Key variables influencing the long-term outcome after ICH are …

Long‐term mortality in patients with acute severe hypertension is unclear. The authors
aimed to compare short‐term (hospital) and long‐term (12 months) mortality in these …

Hypertensive crisis, defined as an increase in systolic blood pressure> 179 mmHg or
diastolic blood pressure> 109 mmHg, typically causes end-organ damage; the brain is an …

Hypertensive crises are elevations of blood pressure higher than 180/120 mmHg. These can
be urgent or emergent, depending on the presence of end organ damage. The clinical …

Sodium nitroprusside (SNP), US approved drug has been used in clinical emergency as a
hypertensive drug for more than a decade. It is well established for its various biomedical …