Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

The NEUROGENINS (NGNs) are neural-specific basic helix–loop–helix (bHLH) transcription
factors. Mouse embryos lacking ngn1 fail to generate the proximal subset of cranial sensory …

Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal
subtype identity with generic features of neuronal differentiation are poorly defined. We …

Neurogenin1 (Ngn1), Neurogenin2 (Ngn2), and Mash1 encode bHLH transcription factors
with neuronal determination functions. In the telencephalon, the Ngns and Mash1 are …

The vertebrate retina contains seven major neuronal and glial cell types in an
interconnected network that collects, processes and sends visual signals through the optic …

Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

Neural stem cells change their characteristics over time during development: they initially
proliferate only and then give rise to neurons first and glial cells later. In the absence of the …

Distinct classes of neurons are generated at defined times and positions during
development of the nervous system. It remains elusive how specification of neuronal identity …

The neural bHLH genes Mash1 and Ngn2 are expressed in complementary populations of
neural progenitors in the central and peripheral nervous systems. Here, we have …