Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …

Muscle stem cells (MuSCs) persist in a quiescent state and activate in response to specific
stimuli. The quiescent state is both actively maintained and dynamically regulated. However …

Advances in cancer immunotherapies make it critical to identify genes that modulate antigen
presentation and tumor-immune interactions. We report that DUX4, an early embryonic …

The genomic, epigenetic and metabolic determinants of prostate cancer pathobiology have
been extensively studied in epithelial cancer cells. However, malignant cells constantly …

Genetic variants have been associated with myriad molecular phenotypes that provide new
insight into the range of mechanisms underlying genetic traits and diseases. Identifying any …

Prostate cancer is a heterogeneous disease composed of divergent molecular and
histologic subtypes, including prostate adenocarcinoma (PrAd) and neuroendocrine …

COVID-19 pandemic has infected more than 154 million people worldwide and caused
more than 3.2 million deaths. It is transmitted by the Severe Acute Respiratory Syndrome …

The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …