Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …

Mitochondria are organelles that play a pivotal role in the production of energy in cells, and
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …

Background Inflammation and myocytes apoptosis play critical roles in the development of
doxorubicin (DOX)-induced cardiotoxicity. Our previous study found that C1q/tumour …

The primary cardiotoxic action of doxorubicin when used as antitumor drug is attributed to
the generation of reactive oxygen species (ROS) therefore effective cardioprotection …

Aims Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately,
the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we …

Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human
neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a …

Cancer is a broad term used to describe a large number of diseases characterized by
uncontrolled cell proliferation that leads to tumor production. Cancer is associated with …

The present study investigates the cardioprotective effect of β-caryophyllene against
doxorubicin-induced acute cardiotoxicity in rats. Doxorubicin (12.5 mg/kg) and β …

Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and
explain the mechanism of this protection. A precise method was elucidated to study the …

Simple Summary The use of date palm pollen ethanolic extract (DPPE) is a conventional
approach in improving the side-effects induced by Doxorubicin (DOX). DPPE mitigated DOX …