Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most aggressive
malignancies with a 5-year survival rate of< 7%. Due to growing incidence, late diagnosis …

The mammalian SWI/SNF chromatin remodeling complex is a heterogeneous collection of
related protein complexes required for gene regulation and genome integrity. It contains a …

Epigenetic regulation of gene expression in cancer cells has been extensively studied in
recent decades, resulting in the FDA approval of multiple epigenetic agents for treating …

The eukaryotic genetic material is packaged in the form of chromatin by wrapping DNA
around nucleosomes. Cells maintain chromatin in a dynamic state by utilising various ATP …

In the last five years, the development of inhibitors of bromodomains has emerged as an
area of intensive worldwide research. Emerging evidence has implicated a number of non …

The DNA-binding AT-rich interactive domain (ARID) exists in a wide range of proteins
throughout eukaryotic kingdoms. ARID domain-containing proteins are involved in manifold …

Long-term azole treatment of patients with chronic Candida albicans infections can lead to
drug resistance. Gain-of-function (GOF) mutations in the transcription factor Mrr1 and the …

Pancreatic cancer is one of the most aggressive human cancer types with a five-year
survival less than 7%. Emerging evidence revealed that many genetic alterations in …

BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that
recruit the complex to chromatin allowing transcriptional activation of several genes. Despite …