Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …
Function of cGMP-dependent protein kinases as revealed by gene deletion
F Hofmann, R Feil, T Kleppisch… - Physiological …, 2006 - journals.physiology.org
Over the past few years, a wealth of biochemical and functional data have been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …
Effect of acute sleep deprivation on vascular function in healthy subjects
F Sauvet, G Leftheriotis… - Journal of applied …, 2010 - journals.physiology.org
Sleep disorders are associated with inflammation and sympathetic activation, which are
suspected to induce endothelial dysfunction, a key factor in the increased risk of …
suspected to induce endothelial dysfunction, a key factor in the increased risk of …
Nitric oxide: orchestrator of endothelium-dependent responses
M Félétou, R Köhler, PM Vanhoutte - Annals of medicine, 2012 - Taylor & Francis
The present review first summarizes the complex chain of events, in endothelial and
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …
Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension
S Brähler, A Kaistha, VJ Schmidt, SE Wölfle… - Circulation, 2009 - Am Heart Assoc
Background—It has been proposed that activation of endothelial SK3 (KCa2. 3) and IK1
(KCa3. 1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium …
(KCa3. 1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium …
The biology of cyclic GMP-dependent protein kinases
F Hofmann - Journal of Biological Chemistry, 2005 - ASBMB
Basic Properties of cGMP-dependent Protein Kinase Isoforms cGKs1 belong to the family of
serine/threonine kinases and are present in a variety of eukaryotes ranging from the …
serine/threonine kinases and are present in a variety of eukaryotes ranging from the …
Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+ …
H Si, WT Heyken, SE Wölfle, M Tysiac… - Circulation …, 2006 - Am Heart Assoc
The endothelium plays a key role in the control of vascular tone and alteration in endothelial
cell function contributes to several cardiovascular disease states. Endothelium-dependent …
cell function contributes to several cardiovascular disease states. Endothelium-dependent …
Vascular smooth muscle phenotypic diversity and function
SA Fisher - Physiological genomics, 2010 - journals.physiology.org
The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …
of blood flow and pressure, and altered regulation is common to diseases such as …
cGMP regulated protein kinases (cGK)
F Hofmann, D Bernhard, R Lukowski… - … generators, effectors and …, 2009 - Springer
Abstract cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are
widely distributed in eukaryotes. Two genes—prkg1 and prkg2—code for cGKs, namely …
widely distributed in eukaryotes. Two genes—prkg1 and prkg2—code for cGKs, namely …
Endothelial Ca2+‐activated K+ channels in normal and impaired EDHF–dilator responses – relevance to cardiovascular pathologies and drug discovery
I Grgic, BP Kaistha, J Hoyer… - British journal of …, 2009 - Wiley Online Library
The arterial endothelium critically contributes to blood pressure control by releasing
vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed …
vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed …