Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

Over the past few years, a wealth of biochemical and functional data have been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …

Sleep disorders are associated with inflammation and sympathetic activation, which are
suspected to induce endothelial dysfunction, a key factor in the increased risk of …

The present review first summarizes the complex chain of events, in endothelial and
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …

Background—It has been proposed that activation of endothelial SK3 (KCa2. 3) and IK1
(KCa3. 1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium …

Basic Properties of cGMP-dependent Protein Kinase Isoforms cGKs1 belong to the family of
serine/threonine kinases and are present in a variety of eukaryotes ranging from the …

The endothelium plays a key role in the control of vascular tone and alteration in endothelial
cell function contributes to several cardiovascular disease states. Endothelium-dependent …

The control of force production in vascular smooth muscle is critical to the normal regulation
of blood flow and pressure, and altered regulation is common to diseases such as …

Abstract cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are
widely distributed in eukaryotes. Two genes—prkg1 and prkg2—code for cGKs, namely …

The arterial endothelium critically contributes to blood pressure control by releasing
vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termed …