From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology

OSM El Nahhas, M van Treeck, G Wölflein, M Unger… - Nature …, 2024 - nature.com
Hematoxylin-and eosin-stained whole-slide images (WSIs) are the foundation of diagnosis
of cancer. In recent years, development of deep learning-based methods in computational …

One label is all you need: Interpretable AI-enhanced histopathology for oncology

TE Tavolara, Z Su, MN Gurcan, MKK Niazi - Seminars in Cancer Biology, 2023 - Elsevier
Artificial Intelligence (AI)-enhanced histopathology presents unprecedented opportunities to
benefit oncology through interpretable methods that require only one overall label per …

Towards a general-purpose foundation model for computational pathology

RJ Chen, T Ding, MY Lu, DFK Williamson, G Jaume… - Nature Medicine, 2024 - nature.com
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks,
requiring the objective characterization of histopathological entities from whole-slide images …

A visual-language foundation model for computational pathology

MY Lu, B Chen, DFK Williamson, RJ Chen, I Liang… - Nature Medicine, 2024 - nature.com
The accelerated adoption of digital pathology and advances in deep learning have enabled
the development of robust models for various pathology tasks across a diverse array of …

Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

SJ Wagner, D Reisenbüchler, NP West, JM Niehues… - Cancer Cell, 2023 - cell.com
Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on …

Scaling self-supervised learning for histopathology with masked image modeling

A Filiot, R Ghermi, A Olivier, P Jacob, L Fidon… - medRxiv, 2023 - medrxiv.org
Computational pathology is revolutionizing the field of pathology by integrating advanced
computer vision and machine learning technologies into diagnostic workflows. It offers …

Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study

JM Niehues, P Quirke, NP West, HI Grabsch… - Cell reports …, 2023 - cell.com
Deep learning (DL) can predict microsatellite instability (MSI) from routine histopathology
slides of colorectal cancer (CRC). However, it is unclear whether DL can also predict other …

Towards a visual-language foundation model for computational pathology

MY Lu, B Chen, DFK Williamson, RJ Chen… - arXiv preprint arXiv …, 2023 - arxiv.org
The accelerated adoption of digital pathology and advances in deep learning have enabled
the development of powerful models for various pathology tasks across a diverse array of …

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

J Calderaro, N Ghaffari Laleh, Q Zeng, P Maille… - Nature …, 2023 - nature.com
Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to
hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined …

Artificial intelligence in clinical oncology: from data to digital pathology and treatment

K Senthil Kumar, V Miskovic, A Blasiak… - American Society of …, 2023 - ascopubs.org
Recently, a wide spectrum of artificial intelligence (AI)–based applications in the broader
categories of digital pathology, biomarker development, and treatment have been explored …