Molecular regulation of vascular smooth muscle cell differentiation in development and disease

GK Owens, MS Kumar… - Physiological reviews, 2004 - journals.physiology.org
The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease

MR Alexander, GK Owens - Annual review of physiology, 2012 - annualreviews.org
The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Signaling mechanisms regulating endothelial permeability

D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Regulation of differentiation of vascular smooth muscle cells

GK Owens - Physiological reviews, 1995 - journals.physiology.org
The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose
principal function is contraction. The fully differentiated or mature SMC proliferates at an …

Urinary bladder contraction and relaxation: physiology and pathophysiology

KE Andersson, A Arner - Physiological reviews, 2004 - journals.physiology.org
The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Signal transduction and regulation in smooth muscle

AP Somlyo, AV Somlyo - Nature, 1994 - nature.com
Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their
abnormalities contribute to a range of diseases. Although based on a sliding-filament …

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

VN Uversky, CJ Oldfield… - Journal of Molecular …, 2005 - Wiley Online Library
Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering

JA Beamish, P He, K Kottke-Marchant… - … Engineering Part B …, 2010 - liebertpub.com
The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular
emphasis on stimuli that promote the contractile phenotype. SMCs can shift reversibly along …

Mechanisms of smooth muscle contraction

A Horowitz, CB Menice, R Laporte… - Physiological …, 1996 - journals.physiology.org
Work performed with differentiated contractile smooth muscle tissue over the last two
decades has made clear that covalent modification of myosin by phosphorylation of the 20 …

On the crawling of animal cells

TP Stossel - Science, 1993 - science.org
Cells crawl in response to external stimuli by extending and remodeling peripheral elastic
lamellae in the direction of locomotion. The remodeling requires vectorial assembly of actin …