In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Purpose: To characterize intraocular pressure (IOP) dynamics by identifying the sources of
transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative …

Rho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and
downstream effector of Rho, is activated by several bioactive factors in the aqueous humor …

We propose an integrated model of aqueous outflow control that employs a pump-conduit
system in this article. Our model exploits accepted physiologic regulatory mechanisms such …

Disclosed herein are systems and methods for aiding a surgeon to perform a surgical
procedure on an eye. The surgical procedure includes inserting an elongate probe from an …

Purpose: The purpose of this study was to estimate human trabecular meshwork (hTM)
stiffness, thought to be elevated in glaucoma, using a novel indirect approach, and to …

Background and objective The trabecular meshwork (TM) consists of extracellular matrix
(ECM) with embedded collagen and elastin fibers providing its mechanical support. TM …

Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …