Epigenetics of breast cancer: Biology and clinical implication in the era of precision medicine
B Pasculli, R Barbano, P Parrella - Seminars in cancer biology, 2018 - Elsevier
In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …
consequence of a more widespread screening resulting in earlier detection, as well as an …
Evolutionary dynamics and molecular mechanisms of HORMA domain protein signaling
Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …
[HTML][HTML] MethylNet: an automated and modular deep learning approach for DNA methylation analysis
Background DNA methylation (DNAm) is an epigenetic regulator of gene expression
programs that can be altered by environmental exposures, aging, and in pathogenesis …
programs that can be altered by environmental exposures, aging, and in pathogenesis …
A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix
Aim: An outstanding challenge in epigenome studies is the estimation of cell-type
proportions in complex epithelial tissues. Materials & methods: Here, we construct and …
proportions in complex epithelial tissues. Materials & methods: Here, we construct and …
[HTML][HTML] Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
BP de Almeida, JD Apolónio, A Binnie… - BMC cancer, 2019 - Springer
Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …
[HTML][HTML] Inhibition of EZH2 catalytic activity selectively targets a metastatic subpopulation in triple-negative breast cancer
Epigenetic changes are increasingly being appreciated as key events in breast cancer
progression. However, breast cancer subtype-specific epigenetic regulation remains poorly …
progression. However, breast cancer subtype-specific epigenetic regulation remains poorly …
[HTML][HTML] MicroRNAs and epigenetics strategies to reverse breast cancer
MM Rahman, AC Brane, TO Tollefsbol - Cells, 2019 - mdpi.com
Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic
instability in breast cancer leads to mutations, copy number variations, and genetic …
instability in breast cancer leads to mutations, copy number variations, and genetic …
[HTML][HTML] EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data
Cell type heterogeneity presents a challenge to the interpretation of epigenome data,
compounded by the difficulty in generating reliable single-cell DNA methylomes for large …
compounded by the difficulty in generating reliable single-cell DNA methylomes for large …
The crucial role of epigenetic regulation in breast cancer anti-estrogen resistance: Current findings and future perspectives
OA Sukocheva, E Lukina, M Friedemann… - Seminars in cancer …, 2022 - Elsevier
Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen
receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity …
receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity …
[HTML][HTML] Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1
expression on pathobiology and clinical response to statins in breast cancer needs …
expression on pathobiology and clinical response to statins in breast cancer needs …