Schistosomiasis is the second most important human parasitic disease in terms of
socioeconomic impact, causing great morbidity and mortality, predominantly across the …

The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Experimental models of Schistosoma mansoni infections in mammals have contributed
greatly to our understanding of the pathology and pathogenesis of infection. We consider …

Recently, we observed that repeated Schistosoma mansoni infection and treatment boost
Th2-associated cytokines and TGF-β production in baboons. Other studies have shown that …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Schistosomiasis is a parasitic disease affecting more than 200 million people. Its major
pathology is granulomatous inffammation, a cellular immune response to antigens secreted …

The complex nature of the schistosome parasite and its interaction with the mammalian host
necessitates the continued use of live intact animal models in schistosomiasis research. This …

Over the past three decades, intensive studies of murine schistosomiasis have provided
important clues to the understanding of the human disease, but growing evidence suggests …

Baboons with primary or secondary exposure to Schistosoma mansoni were compared with
each other over a 12-week infection period and with baseline values obtained from …

This paper analyzed, experimentally, the influences of pattern of exposure, parasite genetic
diversity, and parasite sex on the degree of protection against reinfection with Schistosoma …