Neurological and psychiatric disorders are leading contributors to the global disease
burden, having a serious impact on the quality of life of both patients and their relatives …

The etiology of psychiatric disorders remains largely unknown. The exploration of the
neurobiological mechanisms of mental illness helps improve diagnostic efficacy and …

As the major excitatory neurotransmitter in the mammalian central nervous system,
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …

Exposure to maternal infection in utero increases the risk that offspring will develop
neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia …

Approximately one-third of patients with schizophrenia have treatment-resistant
schizophrenia (TR-SCZ), which is a condition characterized by suboptimal response to …

Schizophrenia is a complex neuropsychiatric illness with marked sex differences. Women
have later onset and lesser symptoms, which has led to the hypothesis that estrogens are …

Background: Glutathione is among the important antioxidants to prevent oxidative stress.
However, the relationships between abnormality in the glutathione system and …

Glial disturbances are highly implicated in the pathophysiology of schizophrenia and may be
linked with glutamatergic dysregulation. Myo-inositol (mI), a putative marker of glial cells …

Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not
adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for …

The extent of age-related changes in glutamate and other neurometabolites in the anterior
cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic …