Adenomatous polyps are the most common neoplastic findings discovered in people who
undergo colorectal screening or who have a diagnostic work-up for symptoms. It was …

Patients with ulcerative colitis and Crohn's disease are at increased risk for developing
colorectal cancer. To date, no known genetic basis has been identified to explain colorectal …

The metastatic process of colorectal cancer (CRC) is not fully understood and effective
therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal …

Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

The progress in our understanding of early events in the development of colonic neoplasia
is the result of 2 advances:(1) improved characterization of lesions detected at endoscopy …

Background and aims: Mutations in BRAF have been linked with colorectal cancers (CRC)
showing high level microsatellite instability (MSI-H). However, the distribution of BRAF …

Colorectal cancer arises in individuals with acquired or inherited genetic predisposition who
are exposed to a range of risk factors. Many of these risk factors are associated with affluent …

The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype
(CIMP), and microsatellite instability (MSI) status in each of the histologic categories …

An appreciation of colonic crypt organization has become essential to any understanding of
tumorigenesis in the colon. Intestinal crypts house tissue-specific, multipotential stem cells …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …