The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities
Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …
Statin drugs to reduce breast cancer recurrence and mortality
Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …
Lipid metabolism in oncology: why it matters, how to research, and how to treat
Y Matsushita, H Nakagawa, K Koike - Cancers, 2021 - mdpi.com
Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …
Statin associated lower cancer risk and related mortality in patients with heart failure
Aims Patients with heart failure (HF) have an increased risk of incident cancer. Data relating
to the association of statin use with cancer risk and cancer-related mortality among patients …
to the association of statin use with cancer risk and cancer-related mortality among patients …
Dysregulation of cholesterol metabolism in cancer progression
X Liu, M Lv, W Zhang, Q Zhan - Oncogene, 2023 - nature.com
Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
M Tajaldini, A Poorkhani, T Amiriani, A Amiriani… - European Journal of …, 2023 - Elsevier
The use of repurposing drugs that may have neoplastic and anticancer effects increases the
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …
Lipid pathway deregulation in advanced prostate cancer
L Galbraith, HY Leung, I Ahmad - Pharmacological research, 2018 - Elsevier
The link between prostate cancer (PC) development and lipid metabolism is well
established, with AR intimately involved in a number of lipogenic processes involving …
established, with AR intimately involved in a number of lipogenic processes involving …
Statins and prostate cancer—hype or hope? The epidemiological perspective
EL Craig, KH Stopsack, E Evergren, LZ Penn… - Prostate cancer and …, 2022 - nature.com
Background Men using cholesterol-lowering statin medications have been found to have
lower risks of both advanced and fatal prostate cancer in multiple registry-based studies and …
lower risks of both advanced and fatal prostate cancer in multiple registry-based studies and …
LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies
Cholesterol is essential for a variety of functions in endocrine-related cells, including
hormone and steroid production. We have reviewed the progress to date in research on the …
hormone and steroid production. We have reviewed the progress to date in research on the …