The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …

Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …

NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia
(AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the …

Simple Summary Venetoclax has proven to be a promising therapy for newly diagnosed,
relapsed and refractory AML patients ineligible for induction chemotherapy. Current ongoing …

PURPOSE Nucleophosmin 1 (NPM1) mutations are associated with a favorable prognosis
in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms …

Abstract Machine learning (ML) is rapidly emerging in several fields of cancer research. ML
algorithms can deal with vast amounts of medical data and provide a better understanding of …

Acute myeloid leukemia (AML) is a genetically heterogeneous clonal malignancy
characterized by recurrent gene mutations. Genomic heterogeneity, patients' individual …

Nucleophosmin (NPM1) is a well‐known nucleocytoplasmic shuttling protein that performs
several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic …

Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the
National Human Genome Research Institute to sequence thousands of tumors representing …

Background Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1), which
displays a distinct long noncoding RNA (lncRNA) expression profile, has been defined as a …