Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Neuro–immune cell units: a new paradigm in physiology

C Godinho-Silva, F Cardoso… - Annual review of …, 2019 - annualreviews.org
The interplay between the immune and nervous systems has been acknowledged in the
past, but only more recent studies have started to unravel the cellular and molecular players …

Novel functional roles for enteric glia in the gastrointestinal tract

BD Gulbransen, KA Sharkey - Nature reviews Gastroenterology & …, 2012 - nature.com
Enteric glia are a unique class of peripheral glial cells within the gastrointestinal tract. Major
populations of enteric glia are found in enteric ganglia in the myenteric and submucosal …

Chemotherapy induced gastrointestinal toxicities

HI Akbarali, KH Muchhala, DK Jessup… - Advances in cancer …, 2022 - Elsevier
Chemotherapy—induced gastrointestinal dysfunction is a common occurrence associated
with many different classes of chemotherapeutic agents. Gastrointestinal toxicity includes …

The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease

M Neunlist, L Van Landeghem, MM Mahé… - Nature reviews …, 2013 - nature.com
The monolayer of columnar epithelial cells lining the gastrointestinal tract—the intestinal
epithelial barrier (IEB)—is the largest exchange surface between the body and the external …

Intestinal stem cell niche: the extracellular matrix and cellular components

L Meran, A Baulies, VSW Li - Stem cells international, 2017 - Wiley Online Library
The intestinal epithelium comprises a monolayer of polarised columnar cells organised
along the crypt‐villus axis. Intestinal stem cells reside at the base of crypts and are …

Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione

TC Savidge, P Newman, C Pothoulakis, A Ruhl… - Gastroenterology, 2007 - Elsevier
Background & Aims: Barrier functions across epithelia and endothelia are essential for
homeostatic tissue regulation. Astroglia interact with cerebral endothelia to maintain the …

Enteric glia regulate gastrointestinal motility but are not required for maintenance of the epithelium in mice

M Rao, D Rastelli, L Dong, S Chiu, W Setlik… - Gastroenterology, 2017 - Elsevier
Background & Aims When the glial fibrillary acidic protein (GFAP) promoter is used to
express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and …

Enteric glia: the most alimentary of all glia

V Grubišić, BD Gulbransen - The Journal of physiology, 2017 - Wiley Online Library
Glia (from Greek γλοία meaning 'glue') pertains to non‐neuronal cells in the central (CNS)
and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In …