In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

Macrophages reside in specific territories in organs, where they contribute to the
development, homeostasis, and repair of tissues. Recent work has shown that the size of …

Airway epithelial cells are unresponsive to endotoxin (lipopolysaccharide (LPS)) exposure
under normal conditions. This study demonstrates that respiratory syncytial virus (RSV) …

Chronic obstructive pulmonary disease (COPD) is caused by the chronic exposure of the
lungs to toxic particles and gases. These exposures initiate a persistent innate and adaptive …

Pathological conditions associated with dysfunctional wound healing are characterized by
impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and …

Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Aberrant tissue repair and persistent inflammation following oxidant-mediated acute lung
injury (ALI) can lead to the development and progression of various pulmonary diseases, but …

Background The multifactorial process of aging predisposes elderly to recurring infections
and inflammatory disorders which ultimately affect quality of life and longevity. Dietary …

An intricate relationship between impaired immune functions and the age-related
accumulation of tissue senescent cells is rapidly emerging. The immune system is unique as …