Comparative evaluation of tumor-infiltrating lymphocytes in companion animals: immuno-oncology as a relevant translational model for cancer therapy
Simple Summary Laboratory experiments studying solid tumors are limited by the inability to
adequately model the tumor microenvironment and important immune interactions. Immune …
adequately model the tumor microenvironment and important immune interactions. Immune …
Review of Molecular Technologies for Investigating Canine Cancer
A Kehl, H Aupperle-Lellbach, S de Brot… - Animals, 2024 - mdpi.com
Simple Summary Genetic molecular testing is starting to become part of standard clinical
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …
Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics
L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey… - Scientific Reports, 2023 - nature.com
Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …
To better understand these similarities, we investigated 671 client-owned dogs from 96 …
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
K Wong, F Abascal, L Ludwig, H Aupperle-Lellbach… - Genome biology, 2023 - Springer
Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and
associated with a poor prognosis. With a high mutation load and large number of altered …
associated with a poor prognosis. With a high mutation load and large number of altered …
[HTML][HTML] Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest …
R Thomas, CA Wiley, EL Droste, J Robertson… - PLoS …, 2023 - journals.plos.org
Molecular profiling studies have shown that 85% of canine urothelial carcinomas (UC)
harbor an activating BRAF V595E mutation, which is orthologous to the V600E variant found …
harbor an activating BRAF V595E mutation, which is orthologous to the V600E variant found …
Precision Medicine in Veterinary Science
E Chon, W Hendricks, M White… - Veterinary Clinics …, 2024 - vetsmall.theclinics.com
The human cancer precision medicine paradigm has been built on the foundation of
understanding cancer's genomic underpinnings and great individual variability Remarkable …
understanding cancer's genomic underpinnings and great individual variability Remarkable …
[HTML][HTML] Comprehensive Analysis of Microsatellite Instability in Canine Cancers: Implications for Comparative Oncology and Personalized Veterinary Medicine
E Mazzone, L Aresu - Animals, 2024 - mdpi.com
Simple Summary This research aims to address the significant knowledge gap regarding
microsatellite instability (MSI) in canine cancers. While MSI has been extensively studied in …
microsatellite instability (MSI) in canine cancers. While MSI has been extensively studied in …
[HTML][HTML] Label-free optical redox ratio from urinary extracellular vesicles as a screening biomarker for bladder cancer
J Park, RL Kamerer, M Marjanovic… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) have been studied for their potential applications in cancer
screening, diagnosis, and treatment monitoring. Most studies have focused on the bulk …
screening, diagnosis, and treatment monitoring. Most studies have focused on the bulk …
Evaluation of PD-1 and PD-L1 expression in canine urothelial carcinoma cell lines
Urothelial carcinoma (UC) is the most common urinary tumor in dogs and despite
combinational therapies, only modest improvements in survival have been achieved in …
combinational therapies, only modest improvements in survival have been achieved in …
The miRNome of canine invasive urothelial carcinoma
MS Varvil, T Bailey, D Dhawan, DW Knapp… - Frontiers in Veterinary …, 2022 - frontiersin.org
Urothelial carcinoma (UC) comprises up to 2% of all naturally occurring neoplasia in dogs
and can be challenging to diagnose. MicroRNAs (miRNAs) have been reported to be …
and can be challenging to diagnose. MicroRNAs (miRNAs) have been reported to be …