Comparative evaluation of tumor-infiltrating lymphocytes in companion animals: immuno-oncology as a relevant translational model for cancer therapy

CJ Pinard, A Lagree, FI Lu, J Klein, ML Oblak… - Cancers, 2022 - mdpi.com
Simple Summary Laboratory experiments studying solid tumors are limited by the inability to
adequately model the tumor microenvironment and important immune interactions. Immune …

Review of Molecular Technologies for Investigating Canine Cancer

A Kehl, H Aupperle-Lellbach, S de Brot… - Animals, 2024 - mdpi.com
Simple Summary Genetic molecular testing is starting to become part of standard clinical
practice for dogs with cancer as it can assist veterinarians with diagnosis, provide …

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics

L Rodrigues, J Watson, Y Feng, B Lewis, G Harvey… - Scientific Reports, 2023 - nature.com
Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer

K Wong, F Abascal, L Ludwig, H Aupperle-Lellbach… - Genome biology, 2023 - Springer
Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and
associated with a poor prognosis. With a high mutation load and large number of altered …

[HTML][HTML] Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest …

R Thomas, CA Wiley, EL Droste, J Robertson… - PLoS …, 2023 - journals.plos.org
Molecular profiling studies have shown that 85% of canine urothelial carcinomas (UC)
harbor an activating BRAF V595E mutation, which is orthologous to the V600E variant found …

Precision Medicine in Veterinary Science

E Chon, W Hendricks, M White… - Veterinary Clinics …, 2024 - vetsmall.theclinics.com
The human cancer precision medicine paradigm has been built on the foundation of
understanding cancer's genomic underpinnings and great individual variability Remarkable …

[HTML][HTML] Comprehensive Analysis of Microsatellite Instability in Canine Cancers: Implications for Comparative Oncology and Personalized Veterinary Medicine

E Mazzone, L Aresu - Animals, 2024 - mdpi.com
Simple Summary This research aims to address the significant knowledge gap regarding
microsatellite instability (MSI) in canine cancers. While MSI has been extensively studied in …

[HTML][HTML] Label-free optical redox ratio from urinary extracellular vesicles as a screening biomarker for bladder cancer

J Park, RL Kamerer, M Marjanovic… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) have been studied for their potential applications in cancer
screening, diagnosis, and treatment monitoring. Most studies have focused on the bulk …

Evaluation of PD-1 and PD-L1 expression in canine urothelial carcinoma cell lines

CJ Pinard, SE Hocker, AC Poon, JM Inkol… - Veterinary Immunology …, 2022 - Elsevier
Urothelial carcinoma (UC) is the most common urinary tumor in dogs and despite
combinational therapies, only modest improvements in survival have been achieved in …

The miRNome of canine invasive urothelial carcinoma

MS Varvil, T Bailey, D Dhawan, DW Knapp… - Frontiers in Veterinary …, 2022 - frontiersin.org
Urothelial carcinoma (UC) comprises up to 2% of all naturally occurring neoplasia in dogs
and can be challenging to diagnose. MicroRNAs (miRNAs) have been reported to be …