Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding
enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to …

Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

The endoplasmic reticulum (ER) is the largest organelle in cells and has fundamental
functions, such as folding, processing, and trafficking of proteins, cellular metabolism, and …

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the
endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy …

Mammalian cells can generate amino acids through macropinocytosis and lysosomal
breakdown of extracellular proteins, which is exploited by cancer cells to grow in nutrient …

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …

Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous
ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit. As the …