COVIDomics: The proteomic and metabolomic signatures of COVID-19

M Costanzo, M Caterino, R Fedele, A Cevenini… - International journal of …, 2022 - mdpi.com
Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

Deciphering the relationship between SARS-CoV-2 and cancer

M Costanzo, MAR De Giglio, GN Roviello - International Journal of …, 2023 - mdpi.com
Some viruses are known to be associated with the onset of specific cancers. These
microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer …

Recommendations for diagnosing and managing individuals with glutaric aciduria type 1: third revision

N Boy, C Mühlhausen, EM Maier… - Journal of inherited …, 2023 - Wiley Online Library
Glutaric aciduria type 1 is a rare inherited neurometabolic disorder of lysine metabolism
caused by pathogenic gene variations in GCDH (cytogenic location: 19p13. 13), resulting in …

The chemical basis of seawater therapies: a review

M Costanzo, MAR De Giglio, M Gilhen-Baker… - Environmental …, 2024 - Springer
The rising number of diseases and deaths caused by pollution and modern lifestyle habits is
a growing societal concern. Marine ecosystems are both victim to this human behaviour as a …

Dynamic interactomics by cross-linking mass spectrometry: mapping the daily cell life in postgenomic era

L Santorelli, M Caterino, M Costanzo - OMICS: A Journal of …, 2022 - liebertpub.com
The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

Sex differences in the human metabolome

M Costanzo, M Caterino, G Sotgiu, M Ruoppolo… - Biology of sex …, 2022 - Springer
Background The sexual dimorphism represents one of the triggers of the metabolic
disparities between the organisms, advising about wild implications in research or …

Toxic metabolites and inborn errors of amino acid metabolism: what one informs about the other

N Lee, D Kim - Metabolites, 2022 - mdpi.com
In inborn errors of metabolism, such as amino acid breakdown disorders, loss of function
mutations in metabolic enzymes within the catabolism pathway lead to an accumulation of …

Metabolic rewiring and autophagy inhibition correct lysosomal storage disease in mucopolysaccharidosis IIIB

M Scarcella, G Scerra, M Ciampa, M Caterino… - Iscience, 2024 - cell.com
Mucopolysaccharidoses (MPSs) are lysosomal disorders with neurological involvement for
which no cure exists. Here, we show that recombinant NK1 fragment of hepatocyte growth …

[HTML][HTML] Proteome data of neuroblastoma cells overexpressing Neuroglobin

M Costanzo, M Caterino, I Salvatori, V Manganelli… - Data in Brief, 2022 - Elsevier
In this article, we present data on the proteome of human neuroblastoma cells stably
overexpressing Neuroglobin (NGB). The neuroprotective role of NGB is clearly established …

Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on targeting capability of nanoparticles

E Imperlini, L Di Marzio, A Cevenini, M Costanzo… - Nanoscale …, 2024 - pubs.rsc.org
Nanoparticles (NPs) interact with biological fluids after being injected into the bloodstream.
The interactions between NPs and plasma proteins at nano-bio interface affect their …