The mitotic spindle uses microtubule-based motor proteins to assemble itself and to
segregate sister chromatids. It is becoming clear that motors invoke several distinct …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells
in mitosis with monoastral spindles. Here, we use monastrol to probe mitotic mechanisms …

Immune cells provide defense against non‐self and have recently been shown to also play
key roles in diverse processes such as development, metabolism, and tumor progression …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

Monastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the
dynamic organization of the mitotic spindle. The mechanism by which monastrol inhibits Eg5 …

We have prepared antibodies specific for HSET, the human homologue of the KAR3 family
of minus end-directed motors. Immuno-EM with these antibodies indicates that HSET …

Accurate segregation of chromosomes during cell division is accomplished through the
assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the …

Background The formation of a bipolar spindle is an essential step during cell division.
Bipolar spindle assembly is driven by the highly conserved microtubule motor Eg5 (kinesin …